Targeting human liver cancer cells with lactobionic acid-G (4)-PAMAM-FITC sorafenib loaded dendrimers
RM Iacobazzi, L Porcelli, AA Lopedota… - International journal of …, 2017 - Elsevier
Reported here is the synthesis and biological evaluation of the asialoglycoprotein receptor
(ASGP-R) targeted fourth generation poliamidoamine dendrimer (G (4)-PAMAM) loaded with
sorafenib. The ASGP-R targeted dendrimer was obtained by conjugation of Lactobionic acid
(La) to the G (4)-PAMAM dendrimer, followed by acetylation (Ac) of the free amino groups in
order to reduce the non-specific interactions with the cell membrane. Moreover, by
additionally grafting fluorescein (FITC), it was easy to characterize the internalization …
(ASGP-R) targeted fourth generation poliamidoamine dendrimer (G (4)-PAMAM) loaded with
sorafenib. The ASGP-R targeted dendrimer was obtained by conjugation of Lactobionic acid
(La) to the G (4)-PAMAM dendrimer, followed by acetylation (Ac) of the free amino groups in
order to reduce the non-specific interactions with the cell membrane. Moreover, by
additionally grafting fluorescein (FITC), it was easy to characterize the internalization …
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